Police are appealing for witnesses following a collision between a train and car in Bairnsdale last Friday night.

The incident occurred at a Ligar Street crossing at around 6.30pm.

The two occupants in the car, both from Bairnsdale, were trapped for some time before being cut free by emergency services.

Both the 19-year-old female driver and the 17-year-old male passenger were airlifted to hospital.

The driver was in a serious but stable condition, the passenger in a critical condition.

The 38 passengers on board the V/Line Traralgon-bound train were transferred to coach services with none reporting any injuries.

The train line remained closed until Saturday morning as police investigated the cause of the collision.

Any witnesses or anyone with information is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report online at www.crimestoppersvic.com.au.